Lisa Xanthopoulou was born in Thessaloniki, were she studied piano, advanced music theory and choral conducting at the State Conservatory and the Music College of Thessaloniki. In 1992, she completed her studies at the Department of Music of the Aristotelian University of Thessaloniki.
In 1998, she graduated from the Universtität der Künste in Berlin, where she studied orchestral conducting with maestros H.M. Rabenstein, H.D. Baum, I. Jackson and M. Husmann. During the course of her studies, she was selected by the German Music Council (Deutscher Musikrat) to participate in their support program for young conductors (Dirigentenforum), where she had the opportunity to work with distinguished maestros such as: K. Sanderling, M. Soustrot, D. Kitajenko, K. Masur, Cl. P. Flor, P. Gulke, B. Kontarsky, J. Kalitzke, and others. In 2002, she was chosen to participate in the Maestros von Morgen program (Tomorrow's Maestros).
She has conducted performances and concerts in Germany, Italy, Cyprus, Turkey, S. Korea and Egypt. Also, she regularly collaborates with all cultural organizations in Greece.
She has received awards at international conducting competitions such as 1st prize at the 2002 Bad Homburg Conductors' Contest and 2nd prize at the 5th A.Pedrotti Conductors' Contest in Trento, Italy, in 1997 (no first prize was awarded that year). She was one of the three finalists in the 5th Conductors' Contest in Cadaques, Spain.
In September 2005, she was appointed Artistic Director of Thessaloniki Opera, the first time this position was introduced. During her administration, in addition to the artistic and administrative development of Thessaloniki Opera, she also established an educational program named "Pes Opera". This pioneering program has familiarized thousands of children and young people with opera as an art form. She introduced the "Pes Opera" Festival, which for two years was the final event of the educational program.
In April 2018 she became Artistic Director of Thessaloniki City Symphony Orchestra.
She has received enthusiastic reviews ever since her very first appearances, both in Greece and abroad.